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Article

CYP2C19 and CYP2J2 genotypes predict praziquantel plasma exposure among Ethiopian school-aged children.

Scientific reports - 22 May 2024

Gebreyesus Tigist Dires, Makonnen Eyasu, Telele Nigus Fikrie, Barry Abbie, Mnkugwe Rajabu Hussein, Gerba Heran, Dahl Marja-Liisa, Aklillu Eleni

Abstract excerpt

Metabolism of praziquantel (PZQ), a racemic mixture and the only drug approved to treat S. mansoni infection, is mediated by genetically polymorphic enzymes. Periodic school-based mass drug administration (MDA) with PZQ is the core intervention to control schistosomiasis. However data on the impact of pharmacogenetic variation, nutrition, and infection status on plasma PZQ exposure is scarce. We investigated...

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Identifiers

PMID: 38778126
DOI: 10.1038/s41598-024-62669-w
PMCID: PMC11111788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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