Article

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery

2025-12-01

Abstract excerpt

Control of schistosomiasis, a neglected tropical disease caused by infection with Schistosoma spp ., remains reliant on a single chemotherapy, praziquantel (PZQ). This strategy presents a risk to global health should PZQ-resistant schistosomes establish in endemic areas and justifies the search for new drugs. However, species-specific metabolic differences between humans and preclinical models hinder the optimisa...

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Literature Corpus work: 85e2cbbd-96af-5efb-8a78-4729c91c6c78
DOI: 10.1101/2025.11.27.690949

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