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Article

In vivo-stable bis-iminobiotin for targeted radionuclide delivery with the mutant streptavidin.

Bioorganic & medicinal chemistry letters - 1 Aug 2024

Tatsumi Toshifumi, Zhao Songji, Kasahara Akitomo, Aoki Miho, Nishijima Ken-Ichi, Ukon Naoyuki, Kodama Tatsuhiko, Takahashi Kazuhiro, Sugiyama Akira, Washiyama Kohshin, Yamatsugu Kenzo, Kanai Motomu

Abstract excerpt

Targeted delivery of radionuclides to tumors is significant in theranostics applications for precision medicine. Pre-targeting, in which a tumor-targeting vehicle and a radionuclide-loaded effector small molecule are administered separately, holds promise since it can reduce unnecessary internal radiation exposure of healthy cells and can minimize radiation decay. The success of the pre-targeting delivery...

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PMID: 38777280
DOI: 10.1016/j.bmcl.2024.129803

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