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Article

Design and synthesis of bis-biotin-containing reagents for applications utilizing monoclonal antibody-based pretargeting systems with streptavidin mutants.

Bioconjugate chemistry - 21 Jul 2010

Wilbur D Scott, Park Steven I, Chyan Ming-Kuan, Wan Feng, Hamlin Donald K, Shenoi Jaideep, Lin Yukang, Wilbur Shani M, Buchegger Franz, Pantelias Anastasia, Pagel John M, Press Oliver W

Abstract excerpt

Previous studies have shown that pretargeting protocols, using cancer-targeting fusion proteins, composed of 4 anti-CD20 single chain Fv (scFv) fragments and streptavidin (scFv(4)-SAv), followed by a biotinylated dendrimeric N-acetyl-galactosamine blood clearing agent (CA), 1, then a radiolabeled DOTA-biotin derivative (a monobiotin), 3a, can provide effective therapy for lymphoma xenografts in mouse models. A...

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Identifiers

PMID: 20597486
DOI: 10.1021/bc100030q
PMCID: PMC2912428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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