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Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels.

Physiological genomics - 15 Mar 2014

Tanisawa Kumpei, Ito Tomoko, Sun Xiaomin, Cao Zhen-Bo, Sakamoto Shizuo, Tanaka Masashi, Higuchi Mitsuru

Abstract excerpt

High cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations. We performed a cross-sectional study to determine whether CRF modifies polygenic risk for dyslipidemia. Serum levels of triglycerides (TG), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C) were measured in 170 Japanese men (age 20-79 yr). CRF...

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Identifiers

PMID: 24474445
DOI: 10.1152/physiolgenomics.00182.2013

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