Article
High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men.
Physiological genomics - 15 Jul 2014
Tanisawa Kumpei, Ito Tomoko, Sun Xiaomin, Ise Ryuken, Oshima Satomi, Cao Zhen-Bo, Sakamoto Shizuo, Tanaka Masashi, Higuchi Mitsuru
Abstract excerpt
High cardiorespiratory fitness (CRF) is associated with a reduced risk of Type 2 diabetes mellitus (T2DM) and improved β-cell function; genetic factors also determine these risks. This cross-sectional study investigated whether CRF modifies the association of polygenic risk of T2DM with glucose metabolism in nondiabetic Japanese men. Fasting plasma glucose, insulin, and glycated hemoglobin (HbA1c) levels were...
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