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Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model.

Translational vision science & technology - 1 May 2024

Hsu Chih-Chien, Chuang Hao-Kai, Hsiao Yu-Jer, Chiang Pin-Hsuan, Chen Szu-Wen, Luo Wei-Ting, Yang Yi-Ping, Tsai Ping-Hsing, Chen Shih-Jen, Hsieh Ai-Ru, Chiou Shih-Hwa

Abstract excerpt

Purpose: The purpose of this study was to conduct a large-scale genome-wide association study (GWAS) and construct a polygenic risk score (PRS) for risk stratification in patients with dry eye disease (DED) using the Taiwan Biobank (TWB) databases. Methods: This retrospective case-control study involved 40,112 subjects of Han Chinese ancestry, sourced from the publicly available TWB. Cases were patients with DED...

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Identifiers

PMID: 38767906
DOI: 10.1167/tvst.13.5.13
PMCID: PMC11114613

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