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Neisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3

18 Jan 2021

Abstract excerpt

(meningococcus) is a common bacterial colonizer of the human nasopharynx but can occasionally cause very severe systemic infections with rapid onset. Meningococci are able to degrade IgA encountered during colonization of mucosal membranes using their IgA1-specific serine protease. During systemic infection, specific IgG can induce complement-mediated lysis of the bacterium. However, meningococcal immune evasion...

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PMID: 33459578
DOI: 10.1080/21505594.2021.1871822

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