Article
Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011
Ruiz-Perez Fernando, Wahid Rezwanul, Faherty Christina S, Kolappaswamy Krishnan, Rodriguez Liliana, Santiago Araceli, Murphy Ebony, Cross Alan, Sztein Marcelo B, Nataro James P
Abstract excerpt
The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway. We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregative Escherichia coli strains, targets a...
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