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Article

Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility.

Laboratory investigation; a journal of technical methods and pathology - 1 Feb 2022

Liu Anthony Pak-Yin, Northcott Paul A, Robinson Giles W, Gajjar Amar

Abstract excerpt

Cell-free DNA (cfDNA) profiling as liquid biopsy has proven value in adult-onset malignancies, serving as a patient-specific surrogate for residual disease and providing a non-invasive tool for serial interrogation of tumor genomics. However, its application in neoplasms of the central nervous system (CNS) has not been as extensively studied. Unique considerations and methodological challenges exist, which need...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34934181
DOI: 10.1038/s41374-021-00719-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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