Article
Residual virulence and immunogenicity of CGV26 and CGV2631 B. melitensis Rev. 1 deletion mutant strains in sheep after subcutaneous or conjunctival vaccination.
Vaccine - 24 Apr 2006
Guilloteau Laurence A, Laroucau Karine, Olivier Michel, Grillo Maria Jesus, Marin Clara M, Verger Jean-Michel, Blasco Jose-Maria
Abstract excerpt
The CGV26 and CGV2631 strains are novel engineered Brucella melitensis Rev.1 mutant strains deleted for the bp26 gene or for both bp26 and omp31 genes, respectively, coding for proteins of diagnostic significance. The residual virulence and immunogenicity of both mutants were compared to the parental Rev.1 strain in sheep after subcutaneous or conjunctival vaccination. The deletion of the bp26 gene or both bp26...
Topics
- Animals
- Antibodies, Bacterial
- Brucella Vaccine
- Brucella ovis
- Brucellosis
- Conjunctiva
- Female
- Injections, Subcutaneous
- Lymphocyte Activation
- Macrophages
- Mutation
- Sheep
- Sheep Diseases