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Article

Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference.

Clinical epigenetics - 2 Mar 2023

Chan Lok Seng, Liu Johnson, Li Molly S C, Li Lili, Tao Qian, Mok Tony S K

Abstract excerpt

BACKGROUND: Selenium, an essential trace element, has previously been investigated as a pro-apoptotic and DNA demethylation agent. It sensitizes the response to chemotherapy in patients who were refractory to cytotoxic agents. Meanwhile, ferroptosis is a novel approach to cancer treatment by triggering cell death and reversing drug resistance. The role of selenium in treating cancer cells harboring druggable...

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Source

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Identifiers

PMID: 36864513
DOI: 10.1186/s13148-023-01454-4
PMCID: PMC9983273

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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