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USP2 reversed cisplatin resistance through p53-mediated ferroptosis in NSCLC

26 Feb 2025

Abstract excerpt

BACKGROUND: It has demonstrated the indispensable role of ferroptosis in conferring cisplatin resistance in non-small cell lung cancer (NSCLC), as well as the involvement of ubiquitin-specific protease (USP) in regulating ferroptosis. This paper aspired to the mechanism of USP2 and ferroptosis on NSCLC cisplatin resistance. METHODS: Ubiquitin-specific protease mRNA expression, was detected through RT-qPCR. In...

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PMID: 40011884
DOI: 10.1186/s12920-025-02108-5

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