Article
Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer.
EBioMedicine - 1 Jun 2024
Papadimitriou Nikos, Kim Andre, Kawaguchi Eric S, Morrison John, Diez-Obrero Virginia, Albanes Demetrius, Berndt Sonja I, Bézieau Stéphane, Bien Stephanie A, Bishop D Timothy, Bouras Emmanouil, Brenner Hermann, Buchanan Daniel D, Campbell Peter T, Carreras-Torres Robert, Chan Andrew T, Chang-Claude Jenny, Conti David V, Devall Matthew A, Dimou Niki, Drew David A, Gruber Stephen B, Harrison Tabitha A, Hoffmeister Michael, Huyghe Jeroen R, Joshi Amit D, Keku Temitope O, Kundaje Anshul, Küry Sébastien, Le Marchand Loic, Lewinger Juan Pablo, Li Li, Lynch Brigid M, Moreno Victor, Newton Christina C, Obón-Santacana Mireia, Ose Jennifer, Pellatt Andrew J, Peoples Anita R, Platz Elizabeth A, Qu Conghui, Rennert Gad, Ruiz-Narvaez Edward, Shcherbina Anna, Stern Mariana C, Su Yu-Ru, Thomas Duncan C, Thomas Claire E, Tian Yu, Tsilidis Konstantinos K, Ulrich Cornelia M, Um Caroline Y, Visvanathan Kala, Wang Jun, White Emily, Woods Michael O, Schmit Stephanie L, Macrae Finlay, Potter John D, Hopper John L, Peters Ulrike, Murphy Neil, Hsu Li, Gunter Marc J, Gauderman W James
Abstract excerpt
BACKGROUND: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations. METHODS: A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we...
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