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Cortisol awakening response and Val66Met BDNF polymorphism interact to shape verbal fluency in aging.

Psychoneuroendocrinology - 1 Oct 2026

Rivas-Diaz Pablo, Trillo-Figueroa David, Peiró Teresa, David-Lluesma Javier, Rivero Olga, SanMiguel Noemi, Hidalgo Vanesa, Salvador Alicia

Abstract excerpt

Neural plasticity is central for cognitive functioning. Across the lifespan, age-related changes in neural plasticity are particularly evident in higher-order cognitive abilities. Among these, verbal fluency (VF) is considered a sensitive marker of cognitive aging, as it reflects the efficient function of both language and executive control systems. VF is commonly differentiated into two subdomains: phonemic...

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Aging
Brain-Derived Neurotrophic Factor
Cognition
Executive Function
Hydrocortisone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuronal Plasticity

Polymorphism, Genetic

Verbal Behavior

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Identifiers

PMID: 42447673
DOI: 10.1016/j.psyneuen.2026.107956

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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