Article
A resampling-based approach to share reference panels.
Nature computational science - 1 May 2024
Cavinato Théo, Rubinacci Simone, Malaspinas Anna-Sapfo, Delaneau Olivier
Abstract excerpt
For many genome-wide association studies, imputing genotypes from a haplotype reference panel is a necessary step. Over the past 15 years, reference panels have become larger and more diverse, leading to improvements in imputation accuracy. However, the latest generation of reference panels is subject to restrictions on data sharing due to concerns about privacy, limiting their usefulness for genotype imputation....
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