Reconstruction of private genomes through reference-based genotype imputation.

Abstract excerpt

BACKGROUND: Genotype imputation is an essential step in genetic studies to improve data quality and statistical power. Public imputation servers are widely used by researchers to impute their data using otherwise access-controlled reference panels of high-fidelity genomes held by these servers. RESULTS: We report evidence against the prevailing assumption that providing access to panels only indirectly via...

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