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Article

Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts.

Cell death and differentiation - 1 Jul 2024

Agarwal Himanshi, Tal Perry, Goldfinger Naomi, Chattopadhyay Esita, Malkin David, Rotter Varda, Attery Ayush

Abstract excerpt

The p53 tumor suppressor, encoded by the TP53 gene, serves as a major barrier against malignant transformation. Patients with Li-Fraumeni syndrome (LFS) inherit a mutated TP53 allele from one parent and a wild-type TP53 allele from the other. Subsequently, the wild-type allele is lost and only the mutant TP53 allele remains. This process, which is termed loss of heterozygosity (LOH), results in only mutant p53...

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Identifiers

PMID: 38745079
DOI: 10.1038/s41418-024-01307-4
PMCID: PMC11239894

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts.PMID 38745079Read ↗

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The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele.Semantic proximity Read ↗

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