Article
Evaluation of the molecular mechanisms involved in the gain of function of a Li-Fraumeni TP53 mutation.
Human mutation - 1 Aug 2005
Capponcelli Silvia, Pedrini Elena, Cerone Maria Antonietta, Corti Valeria, Fontanesi Silvia, Alessio Massimo, Bachi Angela, Soddu Silvia, Ribatti Domenico, Picci Piero, Helman Lee J, Cantelli-Forti Giorgio, Sangiorgi Luca
Abstract excerpt
The TP53 tumor suppressor gene is the most frequent target for genetic alterations in human cancer. TP53 gene alterations may result in the gain of oncogenic functions such as neoangiogenesis and resistance to therapy. The TP53 germ line mutation c.659A>C (p.Y220S) was identified in stored DNA fr...
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