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Strong humoral response after Covid-19 vaccination correlates with the common HLA allele A*03:01 and protection from breakthrough infection.

HLA - 1 Mar 2024

Crocchiolo Roberto, Frassati Coralie, Gallina Anna Maria, Pedini Pascal, Maioli Sandrine, Veronese Luca, Pani Arianna, Scaglione Francesco, D'Amico Federico, Crucitti Lara, Sacchi Nicoletta, Rossini Silvano, Picard Christophe

Abstract excerpt

Few data exist on the role of genetic factors involving the HLA system on response to Covid-19 vaccines. Moving from suggestions of a previous study investigating the association of some HLA alleles with humoral response to BNT162b2, we here compared the HLA allele frequencies among weak (n = 111) and strong (n = 123) responders, defined as those healthcare workers with the lowest and the highest anti-Spike...

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PMID: 38433722
DOI: 10.1111/tan.15421

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