Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.

doi:10.1038/s41591-022-02078-6

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Article

Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection.

Nature medicine - 1 Jan 2023

Mentzer Alexander J, O'Connor Daniel, Bibi Sagida, Chelysheva Irina, Clutterbuck Elizabeth A, Demissie Tesfaye, Dinesh Tanya, Edwards Nick J, Felle Sally, Feng Shuo, Flaxman Amy L, Karp-Tatham Eleanor, Li Grace, Liu Xinxue, Marchevsky Natalie, Godfrey Leila, Makinson Rebecca, Bull Maireid B, Fowler Jamie, Alamad Bana, Malinauskas Tomas, Chong Amanda Y, Sanders Katherine, Shaw Robert H, Voysey Merryn, Snape Matthew D, Pollard Andrew J, Lambe Teresa, Knight Julian C

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity varies between individuals, and immune responses correlate with vaccine efficacy. Using data from 1,076 participants enrolled in ChAdOx1 nCov-19 vaccine efficacy trials in the United Kingdom, we found that inter-individual variation in normalized antibody responses against SARS-CoV-2 spike and its receptor-binding domain (RBD) at...

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Identifiers

PMID: 36228659
DOI: 10.1038/s41591-022-02078-6
PMCID: PMC9873562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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