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Article

A multi-tissue, splicing-based joint transcriptome-wide association study identifies susceptibility genes for breast cancer.

American journal of human genetics - 6 Jun 2024

Gao Guimin, McClellan Julian, Barbeira Alvaro N, Fiorica Peter N, Li James L, Mu Zepeng, Olopade Olufunmilayo I, Huo Dezheng, Im Hae Kyung

Abstract excerpt

Splicing-based transcriptome-wide association studies (splicing-TWASs) of breast cancer have the potential to identify susceptibility genes. However, existing splicing-TWASs test the association of individual excised introns in breast tissue only and thus have limited power to detect susceptibility genes. In this study, we performed a multi-tissue joint splicing-TWAS that integrated splicing-TWAS signals of...

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Identifiers

PMID: 38733992
DOI: 10.1016/j.ajhg.2024.04.010
PMCID: PMC11179262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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