Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

4 Jan 2021

Abstract excerpt

Myelin destruction and oligodendrocyte (OL) death consequent to metabolic stress is a feature of CNS disorders across the age spectrum. Using cells derived from surgically resected tissue, we demonstrate that young (

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Immune cells in cancer
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33398046
DOI: 10.1038/s42003-020-01557-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathwaysPMID 33398046Read ↗

Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent MannerSemantic proximity Read ↗

Mechanisms of metabolic stress induced cell death of human oligodendrocytes: relevance for progressive multiple sclerosisSemantic proximity Read ↗

Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MSSemantic proximity Read ↗

Accumulation of damaged mitochondria in aging astrocytes due to mitophagy dysfunction: Implications for susceptibility to mitochondrial stressSemantic proximity Read ↗

MCL-1 regulates cellular transitions during oligodendrocyte developmentSemantic proximity Read ↗

Senescent Astrocytes Derived from Human Pluripotent Stem Cells Reveal Age-Related Changes and Implications for NeurodegenerationSemantic proximity Read ↗

Environmental and Nutritional “Stressors” and Oligodendrocyte Dysfunction: Role of Mitochondrial and Endoplasmatic Reticulum ImpairmentSemantic proximity Read ↗

Molecular interventions to overcome the ageing of CNS stem cellsSemantic proximity Read ↗

Inhibition of mitochondrial function induces an integrated stress response in oligodendrogliaSemantic proximity Read ↗

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and DiseaseSemantic proximity Read ↗

Neuroinflammation Induces Myelin Damage by Inhibiting Gapdh of Oligodendrocytes in the HippocampusSemantic proximity Read ↗

Bioenergetic dysfunction and inflammation in hiPSC-derived astrocytes from m.14484T>C Leber’s Hereditary Optic NeuropathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.