Article

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

2019-11-29

Abstract excerpt

BICD2 is a key component of the dynein/dynactin motor complex. Autosomal dominant mutations in BICD2 cause Spinal Muscular Atrophy Lower Extremity Predominant 2 (SMALED2), a developmental disease of motor neurons. In this study we sought to examine the motor neuron phenotype of conditional Bicd2 −/− mice. Bicd2 −/− mice show a significant reduction in the number of motor axons of the L4 ventral root compared to...

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Literature Corpus work: 3f0ec6aa-5245-576d-92fc-e87ddbebe873
DOI: 10.1101/854711

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