Article
Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria.
Frontiers in cellular and infection microbiology - 1 Jan 2024
Ajibaye Olusola, Olukosi Yetunde Adeola, Oriero Eniyou C, Oboh Mary Aigbiremo, Iwalokun Bamidele, Nwankwo Ikechukwu Chidiebere, Nnam Chinaza Favour, Adaramoye Olawunmi Victoria, Chukwemeka Somadina, Okanazu Judith, Gabriel Eniafe, Balogun Emmanuel Oluwadare, Amambua-Ngwa Alfred
Abstract excerpt
Background: Routine surveillance for antimalarial drug resistance is critical to sustaining the efficacy of artemisinin-based Combination Therapies (ACTs). Plasmodium falciparum kelch-13 (Pfkelch-13) and non-Pfkelch-13 artemisinin (ART) resistance-associated mutations are uncommon in Africa. We investigated polymorphisms in Plasmodium falciparum actin-binding protein (Pfcoronin) associated with in vivo reduced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.