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Article

A comprehensive genetic map of cytokine responses in Lyme borreliosis.

Nature communications - 7 May 2024

Botey-Bataller Javier, Vrijmoeth Hedwig D, Ursinus Jeanine, Kullberg Bart-Jan, van den Wijngaard Cees C, Ter Hofstede Hadewych, Alaswad Ahmed, Gupta Manoj K, Roesner Lennart M, Huehn Jochen, Werfel Thomas, Schulz Thomas F, Xu Cheng-Jian, Netea Mihai G, Hovius Joppe W, Joosten Leo A B, Li Yang

Abstract excerpt

The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytokine production capacity before and after antibiotic treatment in 1,060 Lyme borreliosis patients. We observed a negative correlation between antibody production and IL-10 responses, as well as increased...

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Source

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Identifiers

PMID: 38714679
DOI: 10.1038/s41467-024-47505-z
PMCID: PMC11076587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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