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Article

Single cell protein profiling of focal cortical dysplasia in a patient requiring multiple resections.

Acta neuropathologica communications - 13 Mar 2026

Elsayed Nada A, Naftel Robert P, Mobley Bret C, Alexander Allyson L, Toland Angus M, Brockman Asa A, Irish Jonathan M, Ihrie Rebecca A, Ess Kevin C

Abstract excerpt

Epilepsy affects millions worldwide with many failing to respond to standard treatments. Drug-refractory epilepsy requiring surgical intervention often presents due to developmental aberrations, such as focal cortical dysplasia (FCD). In FCD type II, somatic mutations in the mTOR pathway allow excessive activation of the mTOR kinase, causing unregulated cell growth and differentiation. Ex vivo studies of resected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41827061
DOI: 10.1186/s40478-026-02273-3
PMCID: PMC13101127

Genes

AKT3
CUX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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