Article
Prevalence and genetic basis of Mycobacterium tuberculosis resistance to pretomanid in China.
Annals of clinical microbiology and antimicrobials - 3 May 2024
Zhao Bing, Zheng Huiwen, Timm Juliano, Song Zexuan, Pei Shaojun, Xing Ruida, Guo Yajie, Ma Ling, Li Feina, Li Qing, Li Yan, Huang Lin, Teng Chong, Wang Ni, Gupta Aastha, Juneja Sandeep, Huang Fei, Zhao Yanlin, Ou Xichao
Abstract excerpt
BACKGROUND: Pretomanid is a key component of new regimens for the treatment of drug-resistant tuberculosis (TB) which are being rolled out globally. However, there is limited information on the prevalence of pre-existing resistance to the drug. METHODS: To investigate pretomanid resistance rates in China and its underlying genetic basis, as well as to generate additional minimum inhibitory concentration (MIC)...
Topics
- Mycobacterium tuberculosis
- China
- Humans
- Microbial Sensitivity Tests
- Antitubercular Agents
- Tuberculosis, Multidrug-Resistant
- Prevalence
- Nitroimidazoles
- Genotype