Article

Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses <i>in vitro</i> and <i>in vivo</i>

2025-01-25

Abstract excerpt

<h4>Background</h4> Alphaviruses, including chikungunya virus (CHIKV), pose a significant global health threat, yet specific antiviral therapies remain unavailable. <h4>Methods</h4> We evaluated combinations of three oral directly acting antiviral drugs (sofosbuvir (SOF), molnupiravir (MPV), and favipiravir (FAV)), which are approved for other indications, against CHIKV, Semliki Forest virus (SFV), Sindbis virus...

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Literature Corpus work: 443e9e93-1e6f-5429-a72a-92e1e66032ea
DOI: 10.1101/2025.01.24.633564

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