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Combinations of approved oral nucleoside analogues confer potent suppression of alphaviruses in vitro and in vivo

14 May 2025

Abstract excerpt

Alphaviruses, including chikungunya virus (CHIKV), pose a significant global health threat, yet specific antiviral therapies remain unavailable. We evaluated combinations of three oral directly acting antiviral drugs (sofosbuvir (SOF), molnupiravir (MPV), and favipiravir (FAV)), which are approved for other indications, against CHIKV, Semliki Forest virus (SFV), Sindbis virus (SINV), and Venezuelan Equine...

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PMID: 40379030
DOI: 10.1016/j.antiviral.2025.106186

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