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Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation

2 May 2024

Abstract excerpt

BACKGROUND: Liver transplantation is an effective treatment for liver failure. There is a large unmet demand, even as not all donated livers are transplanted. The clinical selection criteria for donor livers based on histopathological evaluation and liver function tests are variable. We integrated transcriptomics and histopathology to characterize donor liver biopsies obtained at the time of organ recovery. We...

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PMID: 38698335
DOI: 10.1186/s12864-024-10362-7

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