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Article

A conserved polar residue plays a critical role in mismatch detection in A-family DNA polymerases.

International journal of biological macromolecules - 1 Jun 2024

Clement Patterson C, Sapam Tuleshwori, Nair Deepak T

Abstract excerpt

In A-family DNA polymerases (dPols), a functional 3'-5' exonuclease activity is known to proofread newly synthesized DNA. The identification of a mismatch in substrate DNA leads to transfer of the primer strand from the polymerase active site to the exonuclease active site. To shed more light regarding the mechanism responsible for the detection of mismatches, we have utilized DNA polymerase 1 from Aquifex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38697428
DOI: 10.1016/j.ijbiomac.2024.131965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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