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Article

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy.

Brain : a journal of neurology - 4 Nov 2024

Böing Carolin, Di Fabrizio Marta, Burger Domenic, Bol John G J M, Huisman Evelien, Rozemuller Annemieke J M, van de Berg Wilma D J, Stahlberg Henning, Lewis Amanda J

Abstract excerpt

Multiple system atrophy is characterized pathologically by the accumulation of alpha-synuclein (aSyn) into glial cytoplasmic inclusions (GCIs). The mechanism underlying the formation of GCIs is not well understood. In this study, correlative light and electron microscopy was employed to investigate aSyn pathology in the substantia nigra and putamen of post-mortem multiple system atrophy brain donors. Three...

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Identifiers

PMID: 38696728
DOI: 10.1093/brain/awae137
PMCID: PMC11531854

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