Article
Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.
PLoS genetics - 1 Apr 2022
Scoggin Kristin, Lynch Rachel, Gupta Jyotsana, Nagarajan Aravindh, Sheffield Maxwell, Elsaadi Ahmed, Bowden Christopher, Aminian Manuchehr, Peterson Amy, Adams L Garry, Kirby Michael, Threadgill David W, Andrews-Polymenis Helene L
Abstract excerpt
Salmonella infections typically cause self-limiting gastroenteritis, but in some individuals these bacteria can spread systemically and cause disseminated disease. Salmonella Typhimurium (STm), which causes severe systemic disease in most inbred mice, has been used as a model for disseminated disease. To screen for new infection phenotypes across a range of host genetics, we orally infected 32 Collaborative Cross...
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