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Transcriptome analysis of cardiac endothelial cells after myocardial infarction reveals temporal changes and long-term deficits

1 May 2024

Abstract excerpt

Endothelial cells (ECs) have essential roles in cardiac tissue repair after myocardial infarction (MI). To establish stage-specific and long-term effects of the ischemic injury on cardiac ECs, we analyzed their transcriptome at landmark time points after MI in mice. We found that early EC response at Day 2 post-MI centered on metabolic changes, acquisition of proinflammatory phenotypes, initiation of the S phase...

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PMID: 38693202
DOI: 10.1038/s41598-024-59155-8

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