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Does Acinetobacter calcoaceticus glucose dehydrogenase produce self-damaging H2O2?

Bioscience reports - 29 May 2024

Lublin Victoria, Kauffmann Brice, Engilberge Sylvain, Durola Fabien, Gounel Sébastien, Bichon Sabrina, Jean Cloée, Mano Nicolas, Giraud Marie-France, Chavas Léonard Michel Gabriel Henri, Thureau Aurélien, Thompson Andrew, Stines-Chaumeil Claire

Abstract excerpt

The soluble glucose dehydrogenase (sGDH) from Acinetobacter calcoaceticus has been widely studied and is used, in biosensors, to detect the presence of glucose, taking advantage of its high turnover and insensitivity to molecular oxygen. This approach, however, presents two drawbacks: the enzyme has broad substrate specificity (leading to imprecise blood glucose measurements) and shows instability over time...

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PMID: 38687614
DOI: 10.1042/BSR20240102
PMCID: PMC11130540

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