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Article

Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.

Journal of hepatology - 1 Aug 2020

Parisinos Constantinos A, Wilman Henry R, Thomas E Louise, Kelly Matt, Nicholls Rowan C, McGonigle John, Neubauer Stefan, Hingorani Aroon D, Patel Riyaz S, Hemingway Harry, Bell Jimmy D, Banerjee Rajarshi, Yaghootkar Hanieh

Abstract excerpt

BACKGROUND & AIMS: MRI-based corrected T1 (cT1) is a non-invasive method to grade the severity of steatohepatitis and liver fibrosis. We aimed to identify genetic variants influencing liver cT1 and use genetics to understand mechanisms underlying liver fibroinflammatory disease and its link with other metabolic traits and diseases. METHODS: First, we performed a genome-wide association study (GWAS) in 14,440...

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Identifiers

PMID: 32247823
DOI: 10.1016/j.jhep.2020.03.032
PMCID: PMC7372222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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