Article

The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation

2019-09-06

Abstract excerpt

A common missense variant in SLC39A8 is convincingly associated with schizophrenia and several additional phenotypes. Homozygous loss-of-function mutations in SLC39A8 result in undetectable serum manganese (Mn) and a Congenital Disorder of Glycosylation (CDG) due to the exquisite sensitivity of glycosyltransferases to Mn concentration. Here, we identified several Mn-related changes in human carriers of the commo...

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Literature Corpus work: 64b7d827-0527-5de7-b6b4-5137d0831b49
DOI: 10.1101/757088

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