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Article

Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance

29 Apr 2024

Abstract excerpt

BACKGROUND: CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not been investigated. METHODS: The proteome-wide deubiquitinase (DUB) screening was used to identify the potential regulator of CDC6. Immunofluorescence,...

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PMID: 38685067
DOI: 10.1186/s12943-024-01996-y

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