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Article

Exposure to air pollution increases susceptibility to ulcerative colitis through epigenetic alterations in CXCR2 and MHC class III region.

EBioMedicine - 1 Dec 2024

Chen Jie, Zhang Han, Fu Tian, Zhao Jianhui, Nowak Jan Krzysztof, Kalla Rahul, Wellens Judith, Yuan Shuai, Noble Alexandra, Ventham Nicholas T, Dunlop Malcolm G, Halfvarson Jonas, Mao Ren, Theodoratou Evropi, Satsangi Jack, Li Xue

Abstract excerpt

BACKGROUND: This study aims to confirm the associations of air pollution with ulcerative colitis (UC) and Crohn's disease (CD); to explore interactions with genetics and lifestyle; and to characterize potential epigenetic mechanisms. METHODS: We identified over 450,000 individuals from the UK Biobank and investigated the relationship between air pollution and incident inflammatory bowel disease (IBD). Cox...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Interleukin-8B

Source

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Identifiers

PMID: 39536393
DOI: 10.1016/j.ebiom.2024.105443
PMCID: PMC11605448

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