Article
Examining the associations between microglia genetic capacity, early life exposures and white matter development at the level of the individual.
Brain, behavior, and immunity - 1 Jul 2024
Chan Shi Yu, Fitzgerald Eamon, Ngoh Zhen Ming, Lee Janice, Chuah Jasmine, Chia Joanne S M, Fortier Marielle V, Tham Elizabeth H, Zhou Juan H, Silveira Patricia P, Meaney Michael J, Tan Ai Peng
Abstract excerpt
There are inter-individual differences in susceptibility to the influence of early life experiences for which the underlying neurobiological mechanisms are poorly understood. Microglia play a role in environmental surveillance and may influence individual susceptibility to environmental factors. As an index of neurodevelopment, we estimated individual slopes of mean white matter fractional anisotropy (WM-FA)...
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