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Gene-environment interactions in the influence of maternal education on adolescent neurodevelopment using ABCD study.

Science advances - 15 Nov 2024

Shi Runye, Chang Xiao, Banaschewski Tobias, Barker Gareth J, Bokde Arun L W, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Gowland Penny, Heinz Andreas, Brühl Rüdiger, Martinot Jean-Luc, Martinot Marie-Laure Paillère, Artiges Eric, Nees Frauke, Orfanos Dimitri Papadopoulos, Poustka Luise, Hohmann Sarah, Holz Nathalie, Smolka Michael N, Vaidya Nilakshi, Walter Henrik, Whelan Robert, Schumann Gunter, Lin Xiaolei, Feng Jianfeng

Abstract excerpt

Maternal education was strongly correlated with adolescent brain morphology, cognitive performances, and mental health. However, the molecular basis for the effects of maternal education on the structural neurodevelopment remains unknown. Here, we conducted gene-environment-wide interaction study using the Adolescent Brain Cognitive Development cohort. Seven genomic loci with significant gene-environment...

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Adolescent
Adolescent Development
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Educational Status

Gene-Environment Interaction

Genome-Wide Association Study

Polymorphism, Single Nucleotide

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PMID: 39546599
DOI: 10.1126/sciadv.adp3751
PMCID: PMC11567010

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