Article
A Case Study of a Rare Undifferentiated Spindle Cell Sarcoma of the Penis: Establishment and Characterization of Patient-Derived Models.
Genes - 28 Mar 2024
Sousa Ariane Cavalcante Dos Santos, Fernandes Bruno Leonardo Nascimento Correa, da Silva Jeronimo Paulo Assis, Stevanato Filho Paulo Roberto, Coimbra Luiza Bitencourt de Carvalho Terci, de Oliveira Beserra Adriano, Alvarenga Ana Luiza, Maida Giovanna, Guimaraes Camila Tokumoto, Nakamuta Ingrid Martinez, Marchi Fabio Albuquerque, Alves Camila, Lichtenfels Martina, de Farias Caroline Brunetto, Kupper Bruna Elisa Catin, Costa Felipe D'Almeida, de Mello Celso Abdon Lopes, Carraro Dirce Maria, Torrezan Giovana Tardin, Lopes Ademar, Dos Santos Tiago Goss
Abstract excerpt
Rare sarcomas present significant treatment challenges compared to more prevalent soft tissue sarcomas due to limited treatment options and a poor understanding of their biology. This study investigates a unique case of penile sarcoma, providing a comprehensive morphological and molecular analysis. Through the creation of experimental patient-derived models-including patient-derived xenograft (PDX), 3D, and...
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