Article
Genomic Frequencies of Dynamic DNA Sequences and Mammalian Lifespan.
Cancer genomics & proteomics - 1 Jan 2000
Martella Marianna, Carlesso Nadia, Waller Zoë A E, Marcucci Guido, Pichiorri Flavia, Smith Steven S
Abstract excerpt
BACKGROUND/AIM: Dynamic DNA sequences (i.e. sequences capable of forming hairpins, G-quadruplexes, i-motifs, and triple helices) can cause replication stress and associated mutations. One example of such a sequence occurs in the RACK7 gene in human DNA. Since this sequence forms i-motif structures at neutral pH that cause replication stress and result in spontaneous deletions in prostate cancer cells, our initial...
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