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Article

Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2024

Lan Qiumei, Li Jie, Zhang Hanqing, Zhou Zijun, Fang Yaxuan, Yang Bo

Abstract excerpt

Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic explanation for autosomal dominant polycystic kidney disease is the double-hit theory, and many of its mechanistic issues can be explained by the cilia doctrine....

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Identifiers

PMID: 38668786
DOI: 10.1007/s00109-024-02446-4

Genes

PKD1
PKD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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