Article
Germline Testing Identifies Pathogenic/Likely Pathogenic Variants in Patients with Pancreatic Neuroendocrine Tumors.
Cancer prevention research (Philadelphia, Pa.) - 2 Jul 2024
Mohindroo Chirayu, Baydogan Seyda, Agarwal Parul, Wright Robin D, Prakash Laura R, Mork Maureen E, Klein Alison P, Laheru Daniel A, Maxwell Jessica E, Katz Matthew H G, Dasari Arvind, Kim Michael P, He Jin, McAllister Florencia, De Jesus-Acosta Ana
Abstract excerpt
Ten percent of pancreatic neuroendocrine tumors (pNET) are related to inherited syndromes (MEN1, MEN4, VHL, NF1, and TSC). Growing evidence suggests that clinically sporadic pNETs can also harbor germline pathogenic variants. In this study, we report the prevalence of pathologic/likely pathologic (P/LP) germline variants in a high-risk cohort and an unselected cohort. We collected clinical data of patients with...
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