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Article

Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2024

Lobato Amanda G, Ortiz-Vega Natalie, Zhu Yi, Neupane Deepa, Meier Katlyn K, Zhai R Grace

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder with clinical presentations of moderate to severe cognitive, motor, and psychiatric disturbances. HD is caused by the trinucleotide repeat expansion of CAG of the huntingtin (HTT) gene. The mutant HTT protein containing pathological polyglutamine (polyQ) extension is prone to misfolding and aggregation in the brain. It has previously been...

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Identifiers

PMID: 38660915
DOI: 10.1016/j.bbadis.2023.166928
PMCID: PMC11046041

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