Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila.

Biochimica et biophysica acta - 1 Apr 2016

Zhu Zhou-Jing, Wu Ka-Chun, Yung Wing-Ho, Qian Zhong-Ming, Ke Ya

Abstract excerpt

Alpha-synuclein aggregation is the central hallmark of both sporadic and familial Parkinson's disease (PD). Patients with different PD-causing genetic defects of alpha-synuclein usually show distinctive clinical features that are atypical to sporadic PD. Iron accumulation is invariably found in PD. Recent studies showed that mutant and wild-type alpha-synuclein may have differential interaction with iron and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Motor Neurons

Share to Mutation, Missense

Share to Parkinson Disease

Source

Identifiers

PMID: 26769358
DOI: 10.1016/j.bbadis.2016.01.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential interaction between iron and mutant alpha-synuclein causes distinctive Parkinsonian phenotypes in Drosophila.PMID 26769358Read ↗

α-Synuclein Toxicity in Drosophila melanogaster Is Enhanced by the Presence of Iron: Implications for Parkinson’s DiseaseSemantic proximity Read ↗

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.Semantic proximity Read ↗

Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein AggregationSemantic proximity Read ↗

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model.Semantic proximity Read ↗

Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.Semantic proximity Read ↗

H63D variant of the homeostatic iron regulator (HFE) gene alters α-synuclein expression, aggregation, and toxicity.Semantic proximity Read ↗

Transferrin1 modulates rotenone-induced Parkinson's disease through affecting iron homeostasis in Drosophila melanogaster.Semantic proximity Read ↗

Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease.Semantic proximity Read ↗

A Drosophila model of Parkinson's disease.Semantic proximity Read ↗

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's diseaseSemantic proximity Read ↗

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.Semantic proximity Read ↗

Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.