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Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity

2024-02-09

Abstract excerpt

<title>Abstract</title> <p>Fibrotic remodeling of nucleus pulposus (NP) leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration, leading to low back pain incidence and disability. Emergence of fibroblastic cells in disc degeneration has been reported, yet their nature and origin remain elusive. In this study, we performed an integrative analysis of multiple single-cell RNA...

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Literature Corpus work
1258ac51-a097-57f8-93fb-4681b1bec522
DOI
10.21203/rs.3.rs-3932616/v1
Open publication

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Monocytic fibrocyte-like cell enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severityDOI 10.21203/rs.3.rs-3932616/v1
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