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Article

Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure.

Translational psychiatry - 22 Apr 2024

Caseras Xavier, Simmonds Emily, Pardiñas Antonio F, Anney Richard, Legge Sophie E, Walters James T R, Harrison Neil A, O'Donovan Michael C, Escott-Price Valentina

Abstract excerpt

Recent research has highlighted the role of complement genes in shaping the microstructure of the brain during early development, and in contributing to common allele risk for Schizophrenia. We hypothesised that common risk variants for schizophrenia within complement genes will associate with structural changes in white matter microstructure within tracts innervating the frontal lobe. Results showed that risk...

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Identifiers

PMID: 38649377
DOI: 10.1038/s41398-024-02910-2
PMCID: PMC11035599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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